AOD 9604 is a peptide fragment derived from the C-terminus region of human growth hormone. It consists of the amino acid sequence
This peptide has generated significant interest due to its potential applications related to fat loss, muscle growth, and anti-aging effects. In this article, we will explore the background, mechanisms of action, and current research on AOD 9604. You can buy aod 9604 from different vendors online as well.
Background on AOD 9604
AOD 9604 was originally developed by the biotechnology company Metabolic Pharmaceuticals in the 1990s. Researchers found that this region of the growth hormone molecule stimulated lipolysis (fat breakdown) without the negative side effects associated with unmodified growth hormone. As a result, AOD 9604 showed promise for treating obesity.
The rights to AOD 9604 were later acquired by the Australian company Monash University. Since then, research has expanded to investigate the potential of this peptide for not only fat loss, but also muscle building and anti-aging benefits. AOD 9604 has not been approved as a drug by major health regulators, but is available as a research peptide.
Mechanisms of Action
AOD 9604 is believed to work through several mechanisms of action to stimulate fat burning, muscle growth, and tissue regeneration:
- Lipolysis – AOD 9604 activates lipolytic and antilipogenic pathways to break down fat stores and decrease fat formation.
- Myogenesis – This peptide may increase proliferation and differentiation of muscle cells to promote muscle growth and repair.
- Cell regeneration – By mimicking a small region of growth hormone, AOD 9604 may stimulate regenerative activities in tissues.
- IGF-1 – AOD 9604 may increase production of insulin-like growth factor 1 (IGF-1), which has anabolic effects in muscle and bone.
Research on Fat Loss Effects
A number of studies have investigated the effects of AOD 9604 on fat loss and obesity:
- In obese rodents, AOD 9604 was found to reduce fat mass without affecting lean body mass or causing adverse cardiovascular effects.
- A 12-week phase II clinical trial on 152 overweight adults found that AOD 9604 significantly reduced fat mass compared to placebo, particularly in abdominal fat. No serious adverse effects were observed.
- According to one study, AOD 9604 stimulates fat metabolism via phosphorylation of the lipid mobilization regulator perilipin A. This provides a potential mechanism for the peptide’s lipolytic effects.
- Combining AOD 9604 with other compounds like carnitine may enhance its ability to stimulate fat burning. One study found the combination substantially increased fat oxidation over carnitine alone. Check out aod 9604 with affordable prices here.
Research on Muscle Building
AOD 9604 has also exhibited the ability to increase muscle mass and strength:
- When given to normally fed rats, AOD 9604 was found to significantly increase muscle mass after only 7 days of treatment.
- In underfed rats, AOD 9604 supplementation for 2 weeks restored muscle mass to levels seen in normally fed rats, despite the deficit in caloric intake.
- One study showed that in myoblasts (muscle progenitor cells), AOD 9604 increased differentiation into mature muscle cells and expression of IGF-1. This provides a cellular mechanism for the peptide’s effects on muscle growth.
- AOD 9604 may also have applications for preserving muscle mass in degenerative muscle conditions. In rodent models, it improved grip strength and mobility in a manner similar to growth hormone.
Due to its regenerative and growth-stimulating activities, AOD 9604 is also being investigated for anti-aging benefits:
- Chronic treatment with AOD 9604 showed anti-aging effects in old rats. Improvements were seen in bone mineral density, skin thickness, and lung inflation volume compared to untreated old rats.
- In human cartilage cells, AOD 9604 exhibited cartilage regeneration abilities similar to growth hormone. The peptide stimulated cell proliferation and production of the cartilage components collagen and proteoglycans.
- AOD 9604 increased proliferation of osteoblasts (bone cell) cultures, suggesting it may help improve bone formation and density. This could counteract age-related bone loss.
- The peptide protected neuronal cells from apoptosis (programmed cell death) in cell models exposed to toxins. This neuroprotective effect could potentially slow brain aging.
AOD 9604 appears relatively safe based on current research. Adverse effects are infrequent and mild. Some studies include:
- Chronic toxicity studies in rats found no adverse effects on standard measures of toxicity up to doses of 500 mcg/kg.
- Phase II clinical trials noticed no significant side effects compared to placebo beyond mild irritation at injection sites.
- AOD 9604 does not interfere with other hormone pathways like insulin, thyroid hormone, and cortisol. It also does not increase prostate cell proliferation.
- One study did note a transient suppressive effect of high doses on endogenous growth hormone production. However, this effect was reversible once treatment stopped.
Future Research Directions
More research is still needed to fully confirm the potential of AOD 9604 in humans. Some future research directions may include:
- Larger, longer-term studies on AOD 9604’s effects on fat, muscle mass, and aging processes in humans.
- Exploring synergistic combinations with other compounds like amino acids, myostatin inhibitors, or exercise.
- Studies on the peptide’s brain penetration and effects on cognition.
- Testing new enhanced delivery methods of AOD 9604 like transdermal gels, controlled-release injections, or orally-stable analogs.
- Investigating the molecular mechanisms behind AOD 9604’s effects on cells.
In summary, AOD 9604 is an intriguing peptide compound that continues to show promise in early research for obesity reduction, muscle growth, and anti-aging. While regulatory approval is still lacking, future studies will help to unlock the full therapeutic potential of AOD 9604.